Balance is the key – for the Blood-Brain Barrier

As the food digests, amino acids – not just L-tryptophan – make their way into the bloodstream. This causes competition among the various amino acids to enter the brain.

“L-tryptophan, which is a bulky amino acid, would have to stand in line to get through the blood-brain barrier with a whole bunch of amino acids,” Somer says. L-tryptophan has to compete with all these other amino acids. It waits in line to get through the blood-brain barrier and very little of it makes it across.

As balance is key for so many things in life it is especially important in regards to nutrition and nutrient absorption. Surrounding the turkey with potatoes, dumplings, stuffing, and pie provides carbohydrates, which in turn stimulates the production and release of insulin into the bloodstream. Insulin signals the uptake of amino acids into the muscles. Due to the rather larger and bulky structure of L-tryptophan, it isn’t able to enter muscles, so it is left behind in the bloodstream. With fewer of the other amino acids in the blood, L-tryptophan has less competition and is more likely to cross the blood-brain barrier.

So after a high-protein meal like turkey, it seems that the small, all-carbohydrate snack/dessert is tryptophan’s ticket across the blood-brain barrier, where it can be converted into serotonin and melatonin, the brain chemicals attributed to happiness and sleepiness.